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Featured Publications

Geoffrey Camirand:

Rothstein, D. M., and G. Camirand. 2015. New insights into the mechanisms of Treg function. Curr Opin Organ Transplant 20:376-384.

Camirand, G., Y. Wang, Y. Lu, Y. Y. Wan, Y. Lin, S. Deng, G. Guz, D. L. Perkins, P. W. Finn, D. L. Farber, R. A. Flavell, W. D. Shlomchik, F. G. Lakkis, C. E. Rudd, and D. M. Rothstein. 2014. CD45 ligation expands Tregs by promoting interactions with DCs. J Clin Invest 124:4603-4613.

David K. C. Cooper:

Ezzelarab, M. B., B. Ekser, A. Azimzadeh, C. C. Lin, Y. Zhao, R. Rodriguez, G. J. Echeverri, H. Iwase, C. Long, H. Hara, D. Ayares, R. N. Pierson, A. W. Thomson, and D. K. Cooper. 2015. Systemic inflammation in xenograft recipients precedes activation of coagulation. Xenotransplantation22:32-47. (describes a new finding – that of a systemic inflammatory response after pig organ transplantation into primates - this needs to be overcome or suppressed)

Iwase, H., H. Liu, M. Wijkstrom, H. Zhou, J. Singh, H. Hara, M. Ezzelarab, C. Long, E. Klein, R. Wagner, C. Phelps, D. Ayares, R. Shapiro, A. Humar, and D. K. Cooper. 2015. Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date.Xenotransplantation 22:302-309. (describes the longest survival (at that time) of a life-supporting pig organ graft (a kidney) in a nonhuman primate)

*Four papers from Dr. Cooper's group were listed in the 10 most cited published in the journal Xenotransplantation in 2015.

Hayato Iwase:

Iwase, H., H. Liu, M. Wijkstrom, H. Zhou, J. Singh, H. Hara, M. Ezzelarab, C. Long, E. Klein, R. Wagner, C. Phelps, D. Ayares, R. Shapiro, A. Humar, and D. K. Cooper. 2015. Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date. Xenotransplantation 22:302-309.*

Iwase, H., B. Ekser, V. Satyananda, J. Bhama, H. Hara, M. Ezzelarab, E. Klein, R. Wagner, C. Long, J. Thacker, J. Li, H. Zhou, M. Jiang, S. Nagaraju, H. Zhou, M. Veroux, P. Bajona, M. Wijkstrom, Y. Wang, C. Phelps, N. Klymiuk, E. Wolf, D. Ayares, and D. K. Cooper. 2015. Pig-to-baboon heterotopic heart transplantation--exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens. Xenotransplantation 22:211-220.*

Iwase, H., B. Ekser, H. Zhou, H. Liu, V. Satyananda, R. Humar, P. Humar, H. Hara, C. Long, J. K. Bhama, P. Bajona, Y. Wang, M. Wijkstrom, D. Ayares, M. B. Ezzelarab, and D. K. Cooper. 2015. Further evidence for sustained systemic inflammation in xenograft recipients (SIXR). Xenotransplantation 22:399-405.

*Dr. Iwase's first 2 listed publications were selected for "Top 10 downloaded and cited articles of 2015 in Xenotransplantation.

Matthew Nicotra: 

Karadge, U. B., M. Gosto, and M. L. Nicotra. 2015. Allorecognition proteins in an invertebrate exhibit homophilic interactions. Curr Biol 25:2845-2850. Featured in commentary: http://www.sciencedirect.com/science/article/pii/S0960982215011641

Parmjeet Randhawa:

Randhawa, P., D. V. Pastrana, G. Zeng, Y. Huang, R. Shapiro, P. Sood, C. Puttarajappa, M. Berger, S. Hariharan, and C. B. Buck. 2015. Commercially available immunoglobulins contain virus neutralizing antibodies against all major genotypes of polyomavirus BK. Am J Transplant 15:1014-1020.

Zhao, X., G. Huang, S. Randhawa, G. Zeng, J. Lunz, and P. Randhawa. 2016. Rejection of the Renal Allograft in the Absence of Demonstrable Antibody and Complement. Transplantation.

Huang, G., G. Zeng, Y. Huang, B. Ramaswami, and P. Randhawa. 2016. Evaluation of the Gastrointestinal Tract as Potential Route of Primary Polyomavirus Infection in Mice. PLoS One 11:e0150786. 
Angus W. Thomson:  
Raich-Regue, D., B. R. Rosborough, A. R. Watson, M. J. McGeachy, H. R. Turnquist, and A. W. Thomson. 2015. mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo. J Immunol 194:4767-4776. (This work reveals the role of mTOR complex 2 in regulation of DC function in relation to control of alloimmunity) 
Yokota, S., O. Yoshida, L. Dou, A. V. Spadaro, K. Isse, M. A. Ross, D. B. Stolz, S. Kimura, Q. Du, A. J. Demetris, A. W. Thomson, and D. A. Geller. 2015. IRF-1 promotes liver transplant ischemia/reperfusion injury via hepatocyte IL-15/IL-15Ralpha production. J Immunol 194:6045-6056. (This work will receive the International Liver Transplantation Society Vanguard Award for Best Basic Science Paper of 2015 by a Young Investigator [Dr. Shinichiro Yokoto])
Ezzelarab, M. B., H. Zhang, H. Guo, L. Lu, A. F. Zahorchak, R. W. Wiseman, M. A. Nalesnik, J. K. Bhama, D. K. Cooper, and A. W. Thomson. 2015. Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients. Am J Transplant In press. (This work urges caution about infusion of regulatory T cells into lympho-depleted organ allograft recipients)
Heth R. Turnquist: 

Liew, F. Y., J. P. Girard, and H. R. Turnquist. 2016. Interleukin-33 in health and disease. Nat Rev Immunol In press.

Reichenbach, D. K., V. Schwarze, B. M. Matta, V. Tkachev, E. Lieberknecht, Q. Liu, B. H. Koehn, D. Pfeifer, P. A. Taylor, G. Prinz, H. Dierbach, N. Stickel, Y. Beck, M. Warncke, T. Junt, A. Schmitt-Graeff, S. Nakae, M. Follo, T. Wertheimer, L. Schwab, J. Devlin, S. C. Watkins, J. Duyster, J. L. Ferrara, H. R. Turnquist*, R. Zeiser, and B. R. Blazar. 2015. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD. Blood 125:3183-3192. (*Co-Senior and Co-Corresponding Author)

Mathews, L. R., J. M. Lott, K. Isse, A. Lesniak, D. Landsittel, A. J. Demetris, Y. Sun, D. F. Mercer, S. A. Webber, A. Zeevi, R. T. Fischer, B. Feingold, and H. R. Turnquist. 2016. Elevated ST2 Distinguishes Incidences of Pediatric Heart and Small Bowel Transplant Rejection. Am J Transplant 16:938-950.

Liu, Q., and H. R. Turnquist. 2016. Controlling the burn and fueling the fire: defining the role for the alarmin interleukin-33 in alloimmunity. Curr Opin Organ Transplant 21:45-52.